Alterations in serum thyroid hormones in euthyroid children with circulating anti-thyroid antibodies

Villalpando, S.; Cisneros, I.; García-Bulnes, G.; Urquieta, B.; Mondragón, L.; Junco, E.; Parra, A.

Acta Endocrinologica 99(4): 500-507

1982


ISSN/ISBN: 0001-5598
PMID: 6803490
Accession: 004703913

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Abstract
Anti-thyroid antibodies are frequently found in otherwise normal populations (4.5-25.8%); however, there is scanty information about thyroid function status in affected individuals. The serum concentrations of TSH, T3 T3 before free radioactivity was precipitated with dextran-coated charcoal and the aliquots were analyzed by paper electrophoresis. Serum samples with high T3 levels bound significantly more radioactivity than normal or T3-free serum (P < 0.001) and an abnormal peak of radioactivity was present in the .gamma. globulin fraction, in the former but not in the latter 2 types of sera. The presence of high serum T3 levels in the absence of clinical symptoms of hyperthyroidism was probably due to sequestration of T3 by the anti-thyroglobulin antibody, which may have cross-reactivity with T3 and T4 as has previously been demonstrated both in animals and humans.