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Altered interrelationship of dopamine prolactin thyrotropin and thyroid hormone in schizophrenic patients



Altered interrelationship of dopamine prolactin thyrotropin and thyroid hormone in schizophrenic patients



European Archives of Psychiatry and Neurological Sciences 234(1): 8-12



Increased dopaminergic activity was postulated to be one of the main causes of schizophrenia. To evaluate this hypothesis further, the interrelation between dopamine [DA], prolactin, TSH and L-thyroxine was studied by determining their concentrations in the serum of 10 acutely ill schizophrenic patients exhibiting distinct stages of process activity and 6 healthy subjects. The level of DA was elevated in the sera of schizophrenic patients, whereas the levels of prolactin, TSH and L-thyroxine were decreased. Increased dopaminergic activity affects pituitary secretory function and decreased .beta.-adrenergic activity may be a consequence of decreased thyroid hormone concentration in plasma.

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Accession: 004705396

Download citation: RISBibTeXText

PMID: 6489401

DOI: 10.1007/bf00432877


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