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Amino acids and peptides part 24 a new efficient asymmetric synthesis of alpha amino acid derivatives with re cycle of a chiral reagent asymmetric alkylation of a chiral schiff base from glycine/



Amino acids and peptides part 24 a new efficient asymmetric synthesis of alpha amino acid derivatives with re cycle of a chiral reagent asymmetric alkylation of a chiral schiff base from glycine/



Chemical and Pharmaceutical Bulletin 26(3): 803-808



An efficient asymmetric synthesis of D-.alpha.-amino acid derivatives (VI) was achieved by alkylation of the Schiff base, prepared from glycine tert-butyl ester and (1S,2S,5S)-2-hydroxypinan-3-one (II), followed by hydrolytic cleavage of the alkylated Schiff base. The chiral source (II) was also recovered in good yield, allowing the proliferation of the asymmetry according to the cycle of the amino acid asymmetric synthesis.

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