An experimental study on changes of the gastric mucosal blood flow and secretory function after partial interruption of the gastric blood flow or trunkal vagotomy

Suzuki, K.

Tokyo Jikeikai Medical Journal 102(6): 1793-1810

1987


Accession: 004726811

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Abstract
There is a close relationship between the gastric secretory or motor function and the gastric blood flow or vagal innervation. It is important to understand their relationship in considering the cause and management of AGML (acute gastric mucosal lesion) or stress ulcer. The present study concerns the relationships between gastric secretion and gastric blood flow and between gastric vagal innervation and gastric secretion or blood flow. The study was carried out with canine models of four different groups: (1) control, (2) ligation of the left gastric artery, (3) ligation of the left and right gastric arteries, (4) ligation of the left gastric artery and trunkal vagotomy. In each group, gastric mucosal blood flow, gastric secretory volume, gastric acid volume, and acidity were measured. The results were as follows: Compared with the control, the mucosal blood flow, gastric secretory volume, gastric acid volume, and gastric acidity all decreased after ligation of the gastric arteries or trunkal vagotomy. The maximum decrease in each category of measurement was obtained after arterial ligation and vagotomy were combined and the averages of the maximum decreases after this combination were 64.6%, 53.5%, 68.1%, and 65.4%, respectively, in mucosal blood flow, gastric secretory volume, gastric acid volume, and gastric acidity. There was no significant difference in the effect between ligation of the left gastric artery alone and that of both the left and right gastric arteries. Such experimental results as mentioned suggest that a high grade reduction of the gastric mucosal blood flow and acid secretion is obtained by interruption of the gastric blood supply and vagotomy.