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Chapter 4,737

Analogs of host specific phyto toxin produced by helminthosporium maydis race t 2. biological activities

Suzuki, Y.; Tegtmeier, K.J.; Daly, J.M.; Knoche, H.W.

Bioorganic Chemistry 11(3): 313-321

1982


ISSN/ISBN: 0045-2068
Accession: 004736827

Inhibition of dark CO2 fixation by susceptible corn leaves was used to compare the relative toxicity of synthetic analogs with that of the host-specific phytotoxin produced by the fungal corn pathogen, H. maydis, race T. Analogs with C15, C25, or C26 chain lengths and 1,5-dioxo-3-hydroxy functions were only slightly less toxic (2-6 .times. 10-7 M) than native T toxin (C35-C45 chain lengths) or its individual components (3 .times. 10-8 M). Like native toxin, analogs were host-specific in that they did not inhibit dark CO2 fixation in leaf tissue of resistant corn at concentrations 102-103 times greater than those effective with susceptible corn. These findings support the structures previously proposed for native T toxin.

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