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Anti convulsant activity of n substituted derivatives of 1 anilino cyclo hexane 1 amide



Anti convulsant activity of n substituted derivatives of 1 anilino cyclo hexane 1 amide



Indian Journal of Pharmacology 14(2): 191-200



Eleven N-substituted derivatives of 1-anilinocyclohexane-1-amide and 1-p-anisidino-cyclohexane-I-amide with different side chains, i.e., dimethylamino, di-n-butylamino, dibenzylamino, piperidino, pyrrolidino and morpholino moieties were synthesized using Mannich reaction. Anticonvulsant activity of these compounds was studied against electroshock and metrazol seizures in albino rats and against strychnine convulsions in frogs. Out of the 11 test compounds, significant protection was observed with 6 compounds against electroshock seizures and with 8 compounds against metrazol seizures. Dibenzylamino and morpholino derivatives of both 1-anilino and 1-p-anisidino moieties showed protection against electroshock and metrazol induced convulsions. None of the test compounds antagonized strychnine convulsions in frogs. Most of the compounds that showed anticonvulsant activity produced sedation and potentiated pentobarbitone hypnosis in albino rats.

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