Anti fertility effects of immunization of female baboons with carboxyl terminal peptides of the beta subunit of human chorionic gonadotropin
Stevens, V.C.; Powell, J.E.; Lee, A.C.; Griffin, D.
Fertility and Sterility 36(1): 98-105
ISSN/ISBN: 0015-0282 Accession: 004757334
Fifteen adult female baboons were immunized with a conjugate of tetanus toxoid coupled with a synthetic carboxyl terminal peptide of the .beta.-subunit of human chorionic gonadotropin and another 15 were immunized with tetanus toxoid. Freund's complete adjuvant was used in all immunizations. All females were placed with males of proven fertility during the 3rd menstrual cycle after the primary immunization and those not sustaining pregnancy were mated in 2 additional consecutive cycles. Four pregnancies occurred following 42 matings in the conjugate-immunized group and 15 pregnancies resulted from 21 matings in the tetanus toxoid-immunized animals. Low levels of antibodies reactive to baboon chorionic gonodotropin were found in the pregnant animals in the conjugate-immunized group.