Anti tumor agents part 2 effect of 5 fluoro uracil and cyclo phosphamide on immunological parameters and liver microsomes of tumor bearing rats

Ogiso, T.; Noda, N.; Masuda, H.; Kato, Y.

Japanese Journal of Pharmacology 28(2): 175-184

1978


ISSN/ISBN: 0021-5198
Accession: 004760422

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
An attempt was made to clarify immunosuppressive properties of antitumor agents by studying the effect of the agents on the thymus, the RES and hepatic drug-metabolizing enzyme activities of tumor (an ascites hepatoma, AH 130 cells)-bearing rats. A drastic decrease in the thymus weight and the total number of lymphocytes and an enhanced activity of thymus alkaline phosphatase were detected by injecting 5-fluorouracil (5FU) or cyclophosphamide (CP) (30 mg each/kg wt, i.p.) daily for 5 days to tumor-bearing rats. The agents did not induce any conspicuous damage in microsomal mixed function oxidase system or the RES. The presence of a 10 day old tumor resulted in an extreme decrease in the weight and lymphocytes of thymus and a partial decrease in the microsomal drug metabolizing enzyme activities and the RES. These antitumor agents may lead to the decline of host-mediated immune mechanism. The multiplication of the tumor cells also appeared to depress the immune functions and the host resistance.