Anti tumor agents part 2 effect of 5 fluoro uracil and cyclo phosphamide on immunological parameters and liver microsomes of tumor bearing rats

Ogiso, T.; Noda, N.; Masuda, H.; Kato, Y.

Japanese Journal of Pharmacology 28(2): 175-184


ISSN/ISBN: 0021-5198
Accession: 004760422

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An attempt was made to clarify immunosuppressive properties of antitumor agents by studying the effect of the agents on the thymus, the RES and hepatic drug-metabolizing enzyme activities of tumor (an ascites hepatoma, AH 130 cells)-bearing rats. A drastic decrease in the thymus weight and the total number of lymphocytes and an enhanced activity of thymus alkaline phosphatase were detected by injecting 5-fluorouracil (5FU) or cyclophosphamide (CP) (30 mg each/kg wt, i.p.) daily for 5 days to tumor-bearing rats. The agents did not induce any conspicuous damage in microsomal mixed function oxidase system or the RES. The presence of a 10 day old tumor resulted in an extreme decrease in the weight and lymphocytes of thymus and a partial decrease in the microsomal drug metabolizing enzyme activities and the RES. These antitumor agents may lead to the decline of host-mediated immune mechanism. The multiplication of the tumor cells also appeared to depress the immune functions and the host resistance.