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Antibody dependent cellular cyto toxicity mediated by sub populations of human thymus derived lymphocytes killing of human erythrocytes and autologous lymphoid cells



Antibody dependent cellular cyto toxicity mediated by sub populations of human thymus derived lymphocytes killing of human erythrocytes and autologous lymphoid cells



Immunology 39(3): 407-416



The cytotoxic capabilities of human T [thymus-derived] lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells were characterized in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin(Ig)G (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (TM) displayed no ADCC activity. TG cell-mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig Null cells and low-affinity E[erythrocyte]-rosette forming cells were also capable of similar ADCC activity against these targets.

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Accession: 004763297

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