Aqueous humor changes after experimental filtering surgery

Radius, R.L.; Herschler, J.; Claflin, A.; Fiorentino, G.

American Journal of Ophthalmology 89(2): 250-254


ISSN/ISBN: 0002-9394
PMID: 6766671
DOI: 10.1016/0002-9394(80)90119-1
Accession: 004776331

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The aqueous humor of rhesus and owl monkeys was studied for its effect on the growth of subconjunctival fibroblasts in tissue culture. Aqueous humor samples obtained before glaucoma surgery inhibited the initiation of growth of fibroblasts. Postoperative aqueous humor samples supported growth of fibroblasts. The change in aqueous humor physiology lasted up to 2 mo. after glaucoma surgery. Material added to the postoperative aqueous humor apparently inactivates an inhibitor normally present in primary aqueous humor or primary aqueous humor, in contrast to secondary aqueous humor, lacks sufficient nutrient material to support fibroblast growth in tissue culture.