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Ascaris suum suppression of reaginic and hem agglutinating antibody responses in the mouse by crude extract and maintenance fluid



Ascaris suum suppression of reaginic and hem agglutinating antibody responses in the mouse by crude extract and maintenance fluid



Experimental Parasitology 47(2): 158-168



Administration i.p. in mice of crude extract (CE) or maintenance fluid (MF) of A. suum in Freund's incomplete adjuvant (FICA) in doses of 200 and 2 (CE) and 4 .mu.g (MF) on Days -4, 0 and +4 relative to the day of the immunization with 10 .mu.g of hen egg white lysozyme (HL) resulted in the suppression of anti-HL reaginic antibody [Ab] responses at varying degrees depending on the dose and their time of administration. Hemagglutinating Ab responses were affected but in a different manner. Treatment with CE on Day -4 resulted in complete suppression of reaginic Ab responses and some degree of suppression of hemagglutinating Ab responses depending on the size of the CE dose. In mice pre-treated with MF, transient suppression was found only for reaginic Ab responses. In mice receiving the treatment of CE on Day 0, 200 .mu.g of CE caused complete suppression of reaginic Ab responses, while 2 .mu.g was less effective. Hemagglutinating Ab responses were suppressed in proportion to the dose. Simultaneous treatment with MF did not cause any suppression of reaginic or hemagglutinating Ab responses. In mice treated with CE on Day +4, reaginic Ab responses were not markedly suppressed and hemagglutinating Ab responses were not altered. Treatment with MF on Day +14 resulted in suppression of reaginic Ab responses during the whole course of the primary response, but had no effect on hemagglutinating Ab responses. When MF was administered 7 days after the priming, no suppressive effect on the Ab responses was demonstrated. If a lower dose (1 .mu.g of HL) was used for the priming, the effect of MF treatment with Day +4 was more pronounced in the primary reaginic Ab response and the secondary response was affected. A comparable suppression of hemagglutinating Ab responses was observed.

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Accession: 004782268

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PMID: 437015


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