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Assessment of drug sensitivity of human leukemic myelo blasts part 2 the toxic effects of cytosine arabinoside on iodine 125 5 iodo 2 deoxy uridine labeled human leukemic myelo blasts in mice



Assessment of drug sensitivity of human leukemic myelo blasts part 2 the toxic effects of cytosine arabinoside on iodine 125 5 iodo 2 deoxy uridine labeled human leukemic myelo blasts in mice



British Journal of Cancer 36(3): 307-312



Leukemia cells from the peripheral blood and bone marrow of patients with acute myeloblastic leukemia were labeled in vitro with [125I]5-iodo-2'-deoxyuridine (IUdR). The myeloblasts were injected into groups of mice and the survival of these cells was estimated by measuring isotope loss, using whole body counting. The isotope excretion from mice treated with various doses of cytosine arabinoside (Ara-C) and those not treated with drugs were compared. This comparison showed that the sensitivity of myeloblasts to the drug varies from patient to patient, and in 1 case was different for myeloblasts from bone marrow and blood from the same patient. The clinical responses of myeloblasts to Ara-C in 6 patients, who had high peripheral blood myeloblast counts, was compared with the sensitivites of their myeloblasts to Ara-C in mice. This comparison indicates that the assay might be a useful way of predicting the response of leukemic cells in patients to cytotoxic agents.

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