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Asymmetry of sodium potassium chloride cotransport in human erythrocytes



Asymmetry of sodium potassium chloride cotransport in human erythrocytes



American Journal of Physiology 254(2 Part 1): C243-C250



The Na-K-Cl cotransport system in human erythrocytes was studied by measuring net influxes and effluxes of Na and K. The influx of K was shown to be stimulated by Na and the influx of Na was stimulated by K, satisfying the fundamental criterion of cotransport. In addition, these mutually stimulating cation influxes had a stoichiometry of 1:1 and were entirely inhibited by furosemide; these results are also consistent with cotransport.

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