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Attempts to propagate the scrapie agent in vitro in mouse neural cells

Markovits, P.; Dormont, D.; Delpech, B.; Court, L.; Latarjet, R.

Comptes Rendus des Seances de l'Academie des Sciences Serie III Sciences de la Vie 293(8): 413-418

1981

ISSN/ISBN: 0249-6313
Accession: 004796278
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Attempts were made to propagate the serapie agent in vitro in mouse glia and neuroblastoma cells. After several passages in vitro, yielding at most 10-9 final dilution of the original material, the extracts of 4 of 7 cultures, when injected i.c. into CD1 mice, produced a deadly disease displaying the clinical and pathological signs characteristic of serapie.

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Related References

Markovits, P.; Dautheville, C.; Dormont, D.; Dianoux, L.; Latarjet, R. 1983: In vitro propagation of the scrapie agent. I. Transformation of mouse glia and neuroblastoma cells after infection with the mouse-adapted scrapie strain c-506 Acta Neuropathologica 60(1-2): 75-80
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