Barriers of peripheral nerve towards exogenous peroxidase in normal and protein deprived rats

Oldfors, A.; Sourander, P.

Acta Neuropathologica 43(1-2): 129-134

1978


ISSN/ISBN: 0001-6322
PMID: 676677
DOI: 10.1007/bf00685007
Accession: 004811812

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Abstract
The protective barriers of the sciatic nerve in protein deprived and normal rats were studied. Horseradish peroxidase (HRP) was applied extraneurally in rats aged between 4-26 wk. The spread of the tracer was investigated 2 h, 24 h and 3 days after application. Passage of tracer into the endoneurium was found in all rats but decreased with age. Within the endoneurium, HRP was phagocytized by normally occurring endoneurial histiocytes, which constitute part of the protective barrier system of peripheral nerves. The functional development of the nerve protective barriers was retarded in protein deprived rats. Observations made in this study support the concept of a transperineurial vesicular transport of macromolecules.

Barriers of peripheral nerve towards exogenous peroxidase in normal and protein deprived rats