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Benzothiazole derivatives part 8 synthesis of some 2 4 alkyl or aryl 2 thiazolyl benzothiazoles and 12 4 alkyl or aryl 2 thiazolylamino benzothiazoles as potential anti inflammatory agents



Benzothiazole derivatives part 8 synthesis of some 2 4 alkyl or aryl 2 thiazolyl benzothiazoles and 12 4 alkyl or aryl 2 thiazolylamino benzothiazoles as potential anti inflammatory agents



Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 15(2): 121-124



A number of 2-(4-alkyl or aryl-2-thiazolyl)benzothiazoles (II) and 2-(4-alkyl or aryl-2-thiazolylamino)benzothiazoles (III) were synthesized by the condensation of 2-benzothiazolethiocarboxamides (VI) and N-(2-benzothiazolyl)thioureas (VII), respectively, with various .alpha.-halogenoketones. None of the compounds shows any significant anti-inflammatory activity against carrageenan-induced rat paw edema.

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