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Beta-adrenergic receptor-linked adenylate cyclase in rat posterior pituitary

Beta-adrenergic receptor-linked adenylate cyclase in rat posterior pituitary

Life Sciences 26(8): 589-594

A specific.beta.-adrenergic-stimulated cyclic AMP generating system was evidenced in rat posterior pituitary. This is clearly demonstrated by the facts that adenylate cyclase (AC) affinity for stimulants was in the order (isoproteronol > norepinephrine > dopamine) and propranolol, a specific.beta.-adrenergic receptor blocker, was the only antagonist of the system. Clonidine and apomorphine were completely inactive, excluding an.alpha.-adrenergic and/or dopaminergic component in this AC system.

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Accession: 004820591

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PMID: 6247595

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