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Bile acids co mutagenic activity in the salmonella mammalian microsome mutagenicity test



Bile acids co mutagenic activity in the salmonella mammalian microsome mutagenicity test



Journal of the National Cancer Institute 59(5): 1557-1560



Of 30 bile acids tested, none was mutagenic in the Salmonella-mammalian-microsome test with indicator strains G46, TA1530, TA1535, TA1536, TA1537, TA1538, TA98 or TA100. When lithocholic acid or 1 of its conjugates was tested with suboptimal amounts of 2-aminoanthracene and phenobarbital-stimulated rat liver homogenate, enhancement and comutagenesis were observed if TA1538 was the indicator strain.

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