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Binding of hyaluronic acid oligo saccharides by cartilage proteo glycan

Binding of hyaluronic acid oligo saccharides by cartilage proteo glycan

Biochemical and Biophysical Research Communications 87(4): 1140-1145

Hyaluronic acid oligosaccharides containing 5 or more disaccharide units from 1:1 complexes with [calf nasal septa] proteoglycan, binding strongly with an association constant K estimated to be at least 50 .mu.M-1. Smaller oligosaccharides appear to bind, K being about 1-2 .mu.M-1. Results are consistent with the observed competitive displacement of macromolecular hyaluronic acid from proteoglycan binding sites by oligosaccharides containing no fewer than 5 disaccharide units.

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Accession: 004826701

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PMID: 465029

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