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Bio transformation of 7 12 di methyl benz a anthracene on the genesis of 7 12 di methyl benz a anthracene trans di hydro diols and 7 12 di methyl benz a anthracene 7 methyl and 12 methyl hydroxylated metabolites



Bio transformation of 7 12 di methyl benz a anthracene on the genesis of 7 12 di methyl benz a anthracene trans di hydro diols and 7 12 di methyl benz a anthracene 7 methyl and 12 methyl hydroxylated metabolites



Biochemical and Biophysical Research Communications 93(3): 782-791



Biotransformation of DMBA (7,12-dimethylbenz(a)anthracene) in various induced and uninduced S-10 fractions in the presence and absence of hepatic mixed function oxidase inhibitors (.alpha.-naphthoflavone, metyrapone, SKF-525A and CS2) is described. Particular attention is paid to the production of dihydrodiols (DHD) and DMBA-7- and 12-methyl hydroxylated metabolites.

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