Biochemical investigations and psychological studies of persons chronically exposed to trichloroethylene with regard to non-exposure intervals

Triebig, G.; Schaller, K.H.; Erzigkeit, H.; Valentin, H.

International Archives of Occupational and Environmental Health 38(3): 149-162

1977


ISSN/ISBN: 0340-0131
PMID: 832911
DOI: 10.1007/bf00378353
Accession: 004833383

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Abstract
Psychological and biochemical examinations were made of 8 chronically exposed persons with 260 mg/m3 (50 ppm) trichloroethylene concentration. Psychological examinations were performed to clarify mental functioning alterations in possible psychoorganic syndrome. In spite of proved incorporation of solvent the results of the psychological tests gave no hints of CNS alteration. Biochemical analysis should show at which concentrations the different parameters appear in humans. The effect of non-exposure intervals on the trichloroethylene, trichloroethanol and trichloroacetic acid levels in blood and urine should also be determined. Excretion of total metabolites and blood levels showed large-scale variations in the examined collective. With the exception of trichloroacetic acid, the blood parameters showed a decreased concentration after non-exposed intervals. This result was also found for the excretion of trichloroacetic acid in urine. During the work-free periods the metabolites of trichloroethylene are eliminated slowly. The threshold value of 250 mg trichloroethanol and trichloroacetic acid/g creatinine tolerated in occupational medicine was surpassed by the collective. The median value was 330 and 319 mg trichloroethanol and trichloroacetic acid/g creatinine, respectively, at the end of a working shift. Increasing the acceptable threshold value in occupational medicine is considered.

Biochemical investigations and psychological studies of persons chronically exposed to trichloroethylene with regard to non-exposure intervals