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Biochemical studies on ginseng saponins 12. effect of ginseng saponin on human serum glutamate pyruvate trans aminase ec 2.6.1.2 in vitro

Park, J.J.; Koo, J.H.; Joo, C.N.

Korean Biochemical Journal 11(3): 161-168

1978


ISSN/ISBN: 0368-4881
Accession: 004834193

The activity of GPT (glutamate-pyruvate transaminase) of normal human blood serum in the presence of ginseng saponin, one of the components of Korean Panax ginseng root, was estimated. The highest GPT activity was observed when the saponin concentration in the assay mixture was 1 .times. 10-7%. When the saponin concentration was > 1 .times. 10-7, the GPT stimulation rate was lowered, suggesting that there is an optimal concentration of the saponin for the maximum GPT activity. Km of GPT for L-alanine in the presence of various amounts of the saponin was determined; Km (0.27 mM) in the presence of 1 .times. 10-7% of saponin was greatly lower than that (0.65 mM) of control. The stimulation effect of moderate amounts of the saponin may be due to a lowering of the Km value.

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