Section 5
Chapter 4,835

Biochemical studies on ginseng saponins part 9 determination of critical micellar concentration of the saponin of korean ginseng roots and its effect on lipid dispersion and enzyme reactions

Joo, C.N.; Lee, S.J.

Korean Biochemical Journal 10(2): 59-70


ISSN/ISBN: 0368-4881
Accession: 004834203

The critical micellar concentration (CMC) of ginseng saponin [Panax ginseng] was determined by osmotic pressure and electric conductivity measurements and it was found that the CMC of the saponin was about 2.0%. When the saponin was added to chicken intestinal lumen fluid, the fluid was dispersed effectively. When the saponin was present together with cholesterol in the mixture, it was found that the CMC of the saponin was lowered greatly down to as small as 0.1%. The CMC of sodium cholate (5 mM) was decreased below 1.0 mM in the presence of 0.1% saponin. Observation of the effect of saponin on several reactions catalyzed by such enzymes as mitochondrial dehydrogenases, alcohol and aldehyde dehydrogenases, isocitrate dehydrogenases and transaminases conducted previously supported the concept that surface activities of the saponin might play a significant role in the enzyme catalyzed reactions.

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