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Biologic variation of human immuno globulin concentrations 1. sex age specific effects on serum levels of immuno globulin g immuno globulin a immuno globulin m and immuno globulin d



Biologic variation of human immuno globulin concentrations 1. sex age specific effects on serum levels of immuno globulin g immuno globulin a immuno globulin m and immuno globulin d



Revue Roumaine de Medecine Medecine Interne 18(3): 323-332



Data on a large, randomly selected [human] population of apparently healthy subjects, aged 10-73 yr, of both sexes were used to derive estimates of the reference intervals for serum levels of IgA, IgG, IgM and IgD. The main effects of age and sex on the mean values were studied by the use of a 2-way analysis of variation model. Except for IgG that showed no sex dependencies, statistically significant sex and age-related differences in mean levels were found for each of the Ig studied. The mean concentrations of both IgA and IgD were higher in males than in females; an inverse relationship was identified for IgM. Serum levels of both IgG and IgA rose gradually with advancing age in either sex; by linear-regression analyses these age dependencies were statistically significant for IgG in males and IgA in both sexes. The age-related changes in either IgM or IgD serum levels were more complex and fitted a quintic function better than a linear one. Apparently any interpretation of Ig values without appropriate consideration of the subject's age and sex is likely to be misleading.

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Accession: 004835759

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