Biological properties of 1 2 benzisothiazole compounds anti spasmodic characteristics of 3 benzyl benzisothiazole derivatives

Plazzi, P.V.; Vitto, M.; Bordi, F.; Chiavarini, M.

Acta Naturalia de l'Ateneo Parmense 18(3): 51-58


Accession: 004838315

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The reactive behavior of 3-chloro-1,2-benzisothiazole with phenylacetonitrile was examined in the same conditions already described for malonic nucleophils, in order to synthetize, by subsequent aminoalkylation 3-benzyl-1,2-benzisothiazole, some compounds which could be possibly related to benzylisoquinoline antispasmodic products. The pharmacological profile of the substances studied (named VI and VII) is that of the drugs endowed with dual activity: parasympatholytic and direct muscle-relaxant. Both effect of the examined compounds were always milder than that of the reference antimuscarinic agent and papaverine, but the balanced ratio of the neutrotropic and myotropic contributions seems interesting.