Biological properties of 2 1 benzisothiazole compounds anti fungal and anti staphylococcal activity of 3 azo methine derivatives

Bellotti, A.; Coghi, E.; Sgorbati, O.

Ateneo Parmense Acta Naturalia 12(2): 123-134


Accession: 004838325

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Some 2,1-benzisothyazol- and 5,7-dichloro-2,1-benzisothiazol-3-azomethines were synthesized and tested on representative microorganisms related to human and phytopathology. A weak activity was generally found in vitro against the phytopathogenic fungi which was greater for the dichloronated nucleus than for the unsubstituted nucleus derivatives and the halogenated parent amine. Among the in vivo tested compounds, only the last showed a fair activity in spraying tests, while in the soil disinfection tests a moderate activity exclusively against Phythium ultimum was seen. No effectiveness was found in vitro against the Candida albicans and Staphylococcus aureus, with the exception of the nitrofurfurol azomethine that also is active below 2 .mu.g/ml.