Biological properties of 2 1 benzisothiazoles part 2 local anesthetic activity of some amides and esters of 2 1 benzisothiazole 3 carboxylic acid

Amoretti, L.; Bellotti, A.; Coghi, E.; Zappia, L.

Ateneo Parmense Acta Naturalia 12(4): 345-360


Accession: 004838333

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A group of N-alkylaminoalkylamides and of alkylaminoalkylesters of the 2,1-benzisothiazole-3-carboxylic acid were synthetized and tested for their local anesthetic properties [in mice, rabbits, and frogs (Rana esculenta)]. These compounds, not previously described were prepared by the reaction of the acid chloride, respectively, with the various N-alkylsubstituted polymethylendiamines and the different alkylaminoalkylalcohols. All compounds were tested in infiltration anesthesia, while some of them were also tested in conduction and surface anesthesia. Most of the tested substances showed local anesthetic properties.