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Bloody tears due to congenital factor VII deficiency


, : Bloody tears due to congenital factor VII deficiency. Annals of Ophthalmology 10(5): 593-594

A case of bloody tears due to the factor VII deficiency in a 3 mo. old male infant is presented. No previous report in the literature of bloody tears due to the factor VII deficiency could be found. Bloody tears secretion is a rare clinical phenomenon. Isolated factor VII deficiency is a rare congenital clotting defect and is transmitted by an autosomal recessive trait. Severe factor deficiency is found in homozygote state, partial deficiency in heterozygote. Clinical aspects are related to factor level and hemorrhage can occur when factor VII concentration falls to 10% or less of its normal plasma level. Bleeding due to decreased formation of extrinsic thromboplastin exhibits a range from harmless bruising to subarachnoidal hemorrhage and it can be detected in any stage of life. Severe factor deficiency becomes manifest in early infancy as well as the newborn period and causes death if bleeding is severe or in the critical areas such as the CNS.

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Accession: 004850728

PMID: 677644

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Related references

Mariani, G.; Herrmann, F.H.; Bernardi, F.; Schved, J.F.; Auerswald, G.; Ingerslev, J., 2000: Clinical manifestations, management, and molecular genetics in congenital factor VII deficiency: the International Registry on Congenital Factor VII Deficiency (IRF7). Blood 96(1): 374-374

Hule, V.; Sabacky, J.; Saxl, O., 1955: A case of congenital deficiency of factor VII (serum prothrombin conversion accelerator deficiency, congenital hypoproconvertinanemia). Helvetica Paediatrica Acta 10(4): 419-426

Pur, S., 1964: Bloody Tears. Ceskoslovenska Oftalmologie 20: 379-381

Wieser, S., 2012: Bloody tears. Also called haemolacria, is a puzzling phenomenon. It is described to be caused by conjunctival inflammation, conjunctival vascular tumours and malformations, hereditary haemorrhagic telangiectasia, tumours of the lachrymal apparatus, corneal vasc...

Ahluwalia, B.K.; Khurana, A.K.; Sood, S., 1987: Bloody tears (haemolacria). Indian Journal of Ophthalmology 35(1): 41-43

Bonavolontà, G.; Sammartino, A., 1981: Bloody tears from an orbital varix. A case of bloody tears associated with an intraorbital varix in a 29 yr old woman who also had mild disturbances of coagulation is described.

Ullah, A.; Badshah, M.; Jamil, U., 2015: An unusual case of bloody tears. Conjunctival bleeding although occurs in many pathological conditions enlisting diseases like purulent conjunctivitis, infection with epstian bar virus, and accidental damage to conjunctiva. We report here a rare case of bloody tears which was acc...

Belliveau, M.J.; Strube, Y.Ning.J.; Dexter, D.F.; Kratky, V., 2013: Bloody tears from lacrimal sac rhinosporidiosis. Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie 47(5): E23-E24

Karslıoğlu, S.; Simşek, I.Bahçeci.; Akbaba, Müslime., 2011: A case of recurrent bloody tears. Well-known causes of blood-tinged epiphora are conjunctival lesions, tumors of the lacrimal apparatus, and systemic bleeding disorders. We describe an unusual patient who presented with recurrent episodes of bloody tearing which began following an...

Belau, P.G.; Rucker, C.W., 1961: Bloody tears: report of case. Proceedings of the Staff Meetings. Mayo Clinic 36: 234-238