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Bloody tears due to congenital factor VII deficiency

Bloody tears due to congenital factor VII deficiency

Annals of Ophthalmology 10(5): 593-594

A case of bloody tears due to the factor VII deficiency in a 3 mo. old male infant is presented. No previous report in the literature of bloody tears due to the factor VII deficiency could be found. Bloody tears secretion is a rare clinical phenomenon. Isolated factor VII deficiency is a rare congenital clotting defect and is transmitted by an autosomal recessive trait. Severe factor deficiency is found in homozygote state, partial deficiency in heterozygote. Clinical aspects are related to factor level and hemorrhage can occur when factor VII concentration falls to 10% or less of its normal plasma level. Bleeding due to decreased formation of extrinsic thromboplastin exhibits a range from harmless bruising to subarachnoidal hemorrhage and it can be detected in any stage of life. Severe factor deficiency becomes manifest in early infancy as well as the newborn period and causes death if bleeding is severe or in the critical areas such as the CNS.

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Accession: 004850728

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PMID: 677644

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