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Bone marrow histopathologic patterns and immunologic phenotype in b cell chronic lymphocytic leukemia



Bone marrow histopathologic patterns and immunologic phenotype in b cell chronic lymphocytic leukemia



Blut 57(1): 19-24



The present work analyzes the clinico-biological and immunological characteristics- the latter hitherto unexplored - of the different bone marrow histopathological patterns of the B-cell chronic lymphocytic leukaemia (B-CLL). In addition, we studied whether any or some of these parameters were able to predict the probability of a particular pattern of bone marrow involvement appearing. Of the 100 B-CLL cases studied 41 had a diffuse pattern and 59 were non-diffuse - interstitial 27, nodular 11 and mixed 21 -. Neither clinical nor immunological differences were observed among the distinct non-diffuse patterns. The patients in the diffuse group displayed an increased incidence of .mu.+ isotype and a higher proportion of HLA-DR and HAN-PC 1 positive cells while, conversely, reactivity with the FMC8 McAb was lower. In addition, patients with a diffuse pattern of BM involvement displayed features of a more extensive disease: a higher incidence of adenopathies (p < 0.05), hepatomegaly (p < 0.01), splenomegaly (p < 0.01), anaemia (p < 0.01) and thrombopenia (p < 0.01) as well as higher levels of peripheral blood lymphocytosis (p < 0.05) and a higher pecentage of BM lymphocytic infiltration (p < 0.001). Multiple regression analysis showed that thrombopenia and splenomegaly were the two most important features in predicting the probability of a diffuse pattern.

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Accession: 004853055

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PMID: 3260526


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