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Bone marrow lymphoid follicles in myelo fibrosis compared with chronic myelogenous leukemia

Bone marrow lymphoid follicles in myelo fibrosis compared with chronic myelogenous leukemia

Nouvelle Revue Francaise d'Hematologie 21(3): 251-256

The trephine bone marrow biopsies of 51 patients with myeloproliferative syndromes were revised searching for lymphoid follicles and lymphoplasmocytosis; 18 of these had idiopathic myelofibrosis and 33 chronic myelogenous leukemia. Six of the 18 biopsies on patients with myelofibrosis showed lymphoid follicles; only 1 of the 33 with chronic myelogenous leukaemia did (P = 0.01, Fisher exact test). Four of the 6 patients with myelofibrosis who had follicles had 2 or more of them. When the pathological pattern of myelofibrosis was considered according to the Lennert classification, significantly more follicles were found in the cellular phase of the disease than in the advanced phases (P = 0.04, Fisher exact test). These findings can be considered as a morphological argument supporting the idea of an immunological mechanism in the development of myelofibrosis.

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Accession: 004853089

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PMID: 296376

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