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Breast cancer incidence among atomic bomb survivors hiroshima and nagasaki 1950 1969



Breast cancer incidence among atomic bomb survivors hiroshima and nagasaki 1950 1969



Journal of the National Cancer Institute 59(3): 799-812



For 1950-69, 231 cases of breast cancer were identified among 63,275 female atomic bomb survivors and nonexposed controls; 187 were among survivors for whom dose estimates were available. The estimated absolute risk per rad was 1.9 excess cases/106 person-years at risk over this period for femals who were 10 yr old or older at the time of bombing (ATB), substantially less than published estimates largely based on X-ray and fluoroscopy data from smaller samples of younger North American women. The Hiroshima and Nagasaki [Japan] dose-response curves were similar, which suggested approximate equivalence of neutron and .gamma. radiations in their carcinogenic effect on breast tissue, and were consistent with a linear model. An identifiable radiation effect was evident before 1955. For women of comparable ages ATB, the time from 1945 to diagnosis did not vary by dose, nor was there evidence that radiation caused breast cancer to develop in these women at earlier ages than usual. No breast cancers were found up to 1969 among atomic bomb survivors under age 10 ATB, nor were any substantial numbers observed until 1960 in those 10-19 yr old ATB. By 1965-69, however, the cohort 10-19 yr old ATB exposed to high or medium doses was experiencing a much greater excess of breast cancer than was observed in women 35 yr old or older ATB who were exposed to any dose level. This suggests that the breast tissues of adolescent females may be more sensitive than those of older women to the effects of ionizing radiation. For each age.cntdot.ATB interval (10-19, 20-34, 35-49 and 50+ yr), women exposed to 100 + rads had, by 1969, already approximated or exceeded their lifetime expectations (after 1950) of breast cancer as calculated from Japanese cancer registry data.

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Accession: 004858215

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PMID: 894745


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