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Butoconazole vaginal inserts for vulvovaginal candidiasis comparison of clotrimazole



Butoconazole vaginal inserts for vulvovaginal candidiasis comparison of clotrimazole



Advances in Therapy 2(2): 60-64



Butoconazole vaginal inserts 50 mg and 100 mg were tested against clotrimazole 200 mg vaginal tablets in the treatment of vulvovaginal candidiasis. According to a parallel, investigator-blind study design, 107 nonpregnant patients with culture-proven Candida albicans vaginal infection were randomly assigned to 1 of the 3 treatment regimens. The treatment effects were assessed 8 and 30 days after treatment completion. At the 8-day follow-up examination, the highest microbiological cure (absence of C. albicans in vaginal cultures) was achieved with the 100 mg butoconazole treatment.sbd.97%, the lowest with clotrimazole.sbd.80%: this difference was statistically significant in favor of butoconazole (P < 0.05). At the 30-day follow-up examination, 75% of patients using 100 mg butoconazole were culture-free of C. albicans, while the cure rate for clotrimazole dropped to 53%. The clinical cure rates (absence of entrance symptoms of vaginitis) were comparable among the 3 treatment regimens at both follow-up examinations (80%-88%). No systemic side effects occurred with any treatment regimen and no patient discontinued the study because of local side effects. The 100 mg butoconazole treatment was most acceptable to the patients.

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