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C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha



C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha



Journal of Experimental Medicine 168(1): 443-448



We have demonstrated that purified C5a is a potent stimulus to huma PBMC secretion of TNF-.alpha., IL-1.beta., and IL-1.alpha., which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-.alpha. and IL-1.beta. secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1.alpha. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.

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Accession: 004864498

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PMID: 3260938

DOI: 10.1084/jem.168.1.443


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