EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Caffeine inhibits the central hypotensive action of propranolol in rats


, : Caffeine inhibits the central hypotensive action of propranolol in rats. West Indian Medical Journal 34(4): 234-237

Rats anaesthetized with alpha-chloralose were used to investigate the effects of caffeine on the central hypotensive action of d,l-propranolol (= propranolol). In these rats, intracisternal injections of graded doses (1.7 pmol to 13.6 pmol) of propranolol produced dose-dependent falls in mean arterial blood pressure (7 .+-. 0.6 mm Hg to 27 .+-. 2 mm Hg) which were inhibited by pretreatment with caffeine at a dose (12.9 pmol, intracisternally) that did not alter basal mean arterial blood pressure. The inhibition was reversible and it had an onset and duration of action of about 10 and 50 minutes respectively. It is concluded that caffeine may reduce the hypotensive response of propranolol during antihypertensive therapy with this drug.


Accession: 004865451

PMID: 4090468

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Reid, J.L.; Tangri, K.K.; Wing, L.M., 1977: The central hypotensive action of clonidine and propranolol in animals and man. Progress in Brain Research 47: 369-383

Kelliher G.J., 1976: Evidence for a central site of action in the hypotensive response to propranolol. Scriabine, Alexander And Charles S Sweet (Ed ) Monographs Of The Physiological Society Of Philadelphia, Vol 2 New Antihypertensive Drugs Proceedings Of The A N Richards Symposium King Of Prussia, Pa , Usa, May 19-20, 1975 Xvii+608p Illus Spectrum Publications Inc : New York, N Y , Usa (Dist By Halsted Press/Wiley, New York, N Y , Usa ) Isbn 0-470-15181-1 257-270

Tackett R.L., 1984: Increased release of dopamine and its relationship to the central hypotensive action of propranolol. Federation Proceedings 43(3): ABSTRACT 1568

Privitera P.J.; Granata A.R.; Reis D.J.; Tackett R.L.; Gaffney T.E., 1985: Rostral ventrolateral medulla mediates the central hypotensive action of propranolol. Society for Neuroscience Abstracts 11(1): 192

Maruyama S., 1980: Some findings on the central mechanism of hypotensive action of propranolol and clonidine in cats. Japanese Journal of Pharmacology 30(SUPPL): 179P

Malinowska, B.; Pietraszek, M.; Chabielska, E.; Buczko, W., 1989: The influence of propranolol on the hypotensive action of ketanserin in normotensive rats. In normotensive rats the effect of different doses of propranolol (1.0, 5.0 and 10.0 mg/kg i.p.) and ketanserin (10.0 mg/kg p.o.) on mean blood pressure and heart rate and on cardiovascular response to noradrenaline (0.1, 0.3, 0.5, 0.7 and 1.0 mic...

Privitera, P.J.; Granata, A.R.; Underwood, M.D.; Gaffney, T.E.; Reis, D.J., 1988: C1 area of the rostral ventrolateral medulla as a site for the central hypotensive action of propranolol. Previous studies suggest that the hypotensive response to centrally administered propranolol results from a drug-induced release of norepinephrine which then stimulates central alpha adrenergic receptors and, as a consequence, arterial pressure is...

Offerhaus, L.; van Zwieten, P.A., 1974: Comparative studies on central factors contributing to the hypotensive action of propranolol, alprenolol, and their enantiomers. Cardiovascular Research 8(4): 488-495

Kelliher G.J.; Buckley J.P., 1969: Differentiation of the central hypotensive action of beta adrenergic blocking agents abstract cat propranolol cardio vasc. Federation Proceedings 28(2): 482

Ksiazek, A.; Kleinrok, Z., 1974: Central action of drugs affecting beta-adrenergic receptor. II. The central action of intraventricularly applicated propranolol in rats. Polish Journal of Pharmacology and Pharmacy 26(3): 297-304