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Caffeine inhibits the central hypotensive action of propranolol in rats

, : Caffeine inhibits the central hypotensive action of propranolol in rats. West Indian Medical Journal 34(4): 234-237

Rats anaesthetized with alpha-chloralose were used to investigate the effects of caffeine on the central hypotensive action of d,l-propranolol (= propranolol). In these rats, intracisternal injections of graded doses (1.7 pmol to 13.6 pmol) of propranolol produced dose-dependent falls in mean arterial blood pressure (7 .+-. 0.6 mm Hg to 27 .+-. 2 mm Hg) which were inhibited by pretreatment with caffeine at a dose (12.9 pmol, intracisternally) that did not alter basal mean arterial blood pressure. The inhibition was reversible and it had an onset and duration of action of about 10 and 50 minutes respectively. It is concluded that caffeine may reduce the hypotensive response of propranolol during antihypertensive therapy with this drug.

Accession: 004865451

PMID: 4090468

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Related references

Reid, J.L.; Tangri, K.K.; Wing, L.M., 1977: The central hypotensive action of clonidine and propranolol in animals and man. Progress in Brain Research 47: 369-383

Kelliher G.J., 1976: Evidence for a central site of action in the hypotensive response to propranolol. Scriabine, Alexander And Charles S Sweet (Ed ) Monographs Of The Physiological Society Of Philadelphia, Vol 2 New Antihypertensive Drugs Proceedings Of The A N Richards Symposium King Of Prussia, Pa , Usa, May 19-20, 1975 Xvii+608p Illus Spectrum Publications Inc : New York, N Y , Usa (Dist By Halsted Press/Wiley, New York, N Y , Usa ) Isbn 0-470-15181-1 257-270

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