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Calcium dependent polymerization of lactoferrin

Calcium dependent polymerization of lactoferrin

Biochemical & Biophysical Research Communications 101(1): 88-95

Lactoferrin, which has a MW of .apprx. 77,000, undergoes polymerization in Ca-containing fluids. The predominant species is a tetramer. Preliminary evidence indicates that the tetramer is also found in human serum, tears and breast milk. When the lactoferrin monomer and the tetramer were tested for biological activity in a system that is known to be highly sensitive to an inhibitory effect of lactoferrin (the production of granulocyte monocyte colony-stimulating activity) only the monomeric form of lactoferrin was inhibitory.

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Accession: 004867728

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PMID: 6793043

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