Cannabinoids in glaucoma II: the effect of different cannabinoids on intraocular pressure of the rabbit
Elsohly, M.A.; Harland, E.C.; Benigni, D.A.; Waller, C.W.
Current Eye Research 3(6): 841-850
ISSN/ISBN: 0271-3683 PMID: 6329602 Accession: 004873582
Different cannabinoids (32) were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of .DELTA.9- and .DELTA.8- THC [tetrahydrocannabinoids] derivatives and metabolites along with other natural and synthetic cannabinoids. In addition, some non-cannabinoid constituents of Cannabis were screened using the same model. All compounds were administered i.v., while only a few were tested topically in mineral oil. Water soluble derivatives of .DELTA.9- and .DELTA.8-THC were prepared and tested topically in aqueous solution. The data revelaed that certain derivatives of .DELTA.9- and .DELTA.8-THC were more active in lowering IOP than the parent cannabinoids. Compounds other than .DELTA.9- and .DELTA.8-THC and their derivatives were shown to have activity.