+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Carcino embryonic antigen in plasma cerebro spinal fluid and cystic fluid of patients with intra cranial tumors



Carcino embryonic antigen in plasma cerebro spinal fluid and cystic fluid of patients with intra cranial tumors



Neurologia Medico-Chirurgica 19(11): 1095-1106



Carcinoembryonic antigen (CEA) in plasma, cerebrospinal fluid (CSF) and cystic fluid of patients with various intracranial tumors were determined by a radioimmunoassay using Dainabot and Roche CEA Kits. Slightly elevated levels of plasma CEA were noted in 6 (4%) out of 161 (6/161) patients with primary brain tumors: gliomas, 3/67; pituitary adenomas, 0/30; meningiomas, 0/28; acoustic neurinomas, 1/12; pineal tumors, 2/12 (germinomas, 1/8; teratoma, 0/1; teratoblastoma 0/1; embryonal carcinoma, 1/1; not verified histologically, 0/1); craniopharyngiomas, 0/6; hemangioblastomas, 0/2; epidermoid tumor, 0/1; reticulum cell sarcoma, 0/1; choroid plexus papilloma, 0/1; chondroma, 0/1. The plasma CEA levels of these 6 patients varied from 2.6-3.8 ng/ml. Seventeen (37%) out of 46 patients with metastatic brain tumor showed definite elevation of CEA levels in plasma, most showing values higher than 5.1 ng/ml (ranging from 3.0 to 2317 ng/ml). CEA in CSF of 55 patients with intracranial tumors were determined. Since CEA levels in CSF obtained from 38 control subjects were mostly 0 ng/ml, ranging from 0 to 0.5 ng/ml, an upper limit of normal CEA level in CSF by 1 step sandwich method was proposed to be 0.5 ng/ml. Significant elevation of CEA levels in CSF was noted in the 1 of 37 patients with primary brain tumors, a patient with pineal germinoma showing a spinal metastasis, and in 8 (44%) out of 18 patients with metastatic brain tumor. All of 6 patients with leptomeningeal carcinomatosis showed elevated levels of CEA in CSF. CEA in cystic fluid were measured in 17 patients with intracranial tumors, including 12 gliomas, 2 craniopharyngiomas, 2 metastatic brain tumors and 1 meningioma. Elevated levels of the tumor fluid CEA were noted in 2 patients with craniopharyngioma (8.6 ng/ml and 11.0 ng/ml, respectively), and in 1 with metastatic brain tumor from breast cancer (14,300 ng/ml). Mean value of the tumor fluid CEA of 12 glioma patients was 0.6 .+-. 0.6 ng/ml. A meningioma and 1 metastatic tumor showed low levels of CEA less than 0.5 ng/ml in the tumor fluids. Study on sequential determination of CEA in plasma or CSF performed on 3 patients revealed that CEA levels were well-correlated with the activity of the tumors and could be used for evaluation of treatment of foreknowledge of recurrence of tumors. Determination of CEA in plasma or CSF is valuable for differential diagnosis between primary and metastatic brain tumors, evaluation of treatments, or fore-knowledge of recurrence of tumors. Determination of CEA in CSF could be very useful especially for diagnosis of leptomeningeal carcinomatosis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 004878889

Download citation: RISBibTeXText

PMID: 93250


Related references

A correlative study of cytology and carcino embryonic antigen determination in cerebro spinal fluid in the diagnosis of breast cancer cerebro meningeal metastases. Archives d'Anatomie et de Cytologie Pathologiques 29(5): 287-290, 1981

Cerebro spinal fluid carcino embryonic antigen in meningeal carcinomatosis from breast cancer. Journal of the American Medical Association 244(14): 1601-1603, 1980

Cerebro spinal fluid drainage for infratentorial tumors in respect of intra cranial decompensation. Acta Neurochirurgica 43(1/2): 128, 1978

Results of continuous lumbar cerebro spinal fluid pressure measurements to investigate intra cranial fluid regulation. Acta Neurochirurgica 26(4): 369, 1972

The cerebro spinal fluid protein pattern in acute cerebellar ataxia of childhood and intra cranial midline tumors. European Journal of Pediatrics 137(1): 49-58, 1981

Carcinoembryonic Antigen in Plasma, Cerebrospinal Fluid and Cystic Fluid of Patients with Intracranial Tumors. Neurologia medico-chirurgica 19(11): 1095-1105, 1979

Pre operative diagnosis of intra cranial germ cell tumors utilizing alpha feto protein and human chorionic gonadotropin determinations in cerebro spinal fluid. Child's Brain 5(6): 554, 1979

Concentration of biogenetic amines and their metabolites in cerebro spinal fluid from the lateral ventricles of patients with intra cranial hematomas. Neurochirurgia (Suppl.): 42, 1981

Alteration of the intra cranial pressure volume relationship following the bolus cerebro spinal fluid manipulation test by various basic intra cranial pressure levels. Nichidai Igaku Zasshi 41(6): 617-636, 1982

Evidence for the release of vasopressin and oxytocin into cerebro spinal fluid measurements in plasma and cerebro spinal fluid of intact and hypophysectomized rats. Neuroendocrinology 24(2): 108-118, 1977

Carcino embryonic antigen in patients with urologic cancer 2. the clinical utility of plasma carcino embryonic antigen and urinary carcino embryonic antigen like substance in urothelial cancer. Acta Urologica Japonica 27(3): 231-241, 1981

Levels of plasma proteins in human and rat fetal cerebro spinal fluid and the development of the blood cerebro spinal fluid barrier. Neuropaediatrie 8(4): 345-353, 1977

Papillo edema cerebro spinal fluid pressure and cerebro spinal fluid flow in cerebral tumors. Journal of Neurology Neurosurgery & Psychiatry 42(6): 493-500, 1979

Uptake of 5 iodine 125 iodo 2 deoxy uridine in plasma and cerebro spinal fluid in a case of herpes encephalitis with a comparative study on the uptake in plasma cerebro spinal fluid and brain tissue in dogs. Scandinavian Journal of Infectious Diseases 9(2): 85-90, 1977

Cerebro spinal fluid lipids in children with and without intra cranial hypertension. Acta Universitatis Carolinae Medica Monographia (75): 167-169, 1977