Carcinogenic activity of ethylene oxide and its reaction products 2 chloroethanol 2 bromoethanol ethylene glycol and diethylene glycol iii. testing of ethylene glycol and diethylene glycol for carcinogenicity

Dunkelberg, H.

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene, Serie B, Umwelthygiene, Krankenhaushygiene, Arbeitshygiene, praventive Medizin 183(4): 358-365

1987


ISSN/ISBN: 0932-6073
Accession: 004879213

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Abstract
Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages (30; 10 and 3 mg single dose per mouse). Tricaprylin was used as solvent. The mean total dosage per mouse was 2110.5; 707.0 and 196.2 mg for ethylene glycol and 2029.8; 671.7 and 213.3 mg for diethylene glycol. Neither ethylene glycol nor diethylene glycol induced tumors at the injection site or away form the point of administration.