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Catabolism of purified rat fibrin(ogen) plasmin degradation products in rats

Catabolism of purified rat fibrin(ogen) plasmin degradation products in rats

Thrombosis and Haemostasis 48(1): 59-61

The blood clearance of purified plasmin degradation products (X, Y, D-dimer, Dcate, D EGTA [ethyleneglycol-bis(.beta. aminoethylether)-N,N,N'N'-tetraacetic acid], E-fibrin, Ecate and E EGTA) of rat fibrin(ogen) was studied in a homologous system. Transcapillary flux rate constants, fractional catabolic rate constants and the ratios of intravascular and extravascular pools were calculated. There are considerable differences in these constants between the 2 early fibrinogen degradation products X and Y. Also, the differences between fibrinogen D and E fragments, derived from different parts of the fibrinogen molecule, are considerable. The differences between fibrin fragment D-dimer and fibrinogen fragment Dcate are relatively small. The differences between fragments E-fibrin, Ecate and E EGTA are also small. The main fraction of all E-fragments is extravascular.

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Accession: 004886481

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PMID: 7135343

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