EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Cell mediated and humoral immune responses in mice part 4 difference of the functional cell population between helper activity and delayed type hyper sensitivity



Cell mediated and humoral immune responses in mice part 4 difference of the functional cell population between helper activity and delayed type hyper sensitivity



Immunology 32(3): 237-245



Helper activity in the anti-hapten antibody response was studied in mice in reference to the induction of delayed-type hypersensitivity (DTH) to the carrier protein. Mice were immunized by an i.v. injection of alum-precipitated bovine serum albumin (AP-BSA) plus bacterial [Escherichia coli] endotoxin or by a s.c. injection of BSA in Freund's complete adjuvant, the latter being effective in inducing DTH. The helper activity was estimated by the antibody response to the challenge with dinitrophenylated BSA (DNP-BSA) given at varying intervals after the injection of BSA. The helper activity was apparently independent of DTH to the carrier protein, suggesting that these 2 activities are mediated by different populations of functional cells. A low dose of tolerogenic soluble BSA (sBSA) was sufficient to abrogate the helper activity in the response to DNP-BSA. DTH to BSA was only partially depressed by the pretreatment with a low dose of sBSA and was completely depressed by a high dose. DTH reactivity in mice pretreated with a low dose of tolerogen and followed by the immunization with BSA in Freund's complete adjuvant was substantiated by the microscopic observation of mononuclear cell infiltration at the site of the test antigen injection. Cells involved in the helper function and DTH may be derived from different precursors.

(PDF emailed within 1 workday: $29.90)

Accession: 004892589

Download citation: RISBibTeXText



Related references

Cell-mediated and humoral immune responses in mice. IV. Difference of the functional cell population between helper activity and delayed-type hypersensitivity. Immunology 32(3): 237-245, 1977

Cell mediated and humoral immune responses in mice part 2 sensitizing conditions for delayed type hyper sensitivity. International Archives of Allergy and Applied Immunology 53(4): 329-340, 1977

Cell mediated and humoral immune responses in mice part 1 necessary conditions for the detection of delayed type hyper sensitivity. International Archives of Allergy and Applied Immunology 53(2): 152-161, 1977

Cell mediated and humoral immune responses in mice part 3 dynamic balance between delayed type hyper sensitivity and antibody response. Immunology 32(3): 227-235, 1977

Genetic regulation of delayed type hyper sensitivity responses to a branched peptide containing tyrosine glutamic acid alanine and lysine 2. evidence for a thymus derived cell thymus derived cell collaboration in delayed type hyper sensitivity responses and for a thymus derived cell defect at the efferent phase in nonresponder h 2k mice. Journal of Experimental Medicine 151(3): 628-636, 1980

Cell-mediated and humoral immune responses in mice. I. Necessary conditions for the detection of delayed-type hypersensitivity. International Archives of Allergy and Applied Immunology 53(2): 152-161, 1977

Cell-mediated and humoral immune responses in mice. II. Sensitizing conditions for delayed-type hypersensitivity. International Archives of Allergy and Applied Immunology 53(4): 329-340, 1977

Studies on delayed hyper sensitivity in mice part 3 evidence for suppressive regulatory thymus derived t 1 cell population in delayed hyper sensitivity. Journal of Experimental Medicine 145(2): 237-248, 1977

Chromium 51 release micro assay technique for cell mediated immunity to mumps virus correlation with humoral and delayed type skin hyper sensitivity responses. Journal of Infectious Diseases 134(6): 546-551, 1976

Cellular and humoral immune responses in mice part 2 effect of intra peritoneal or sub cutaneous injection of carrier on anti hapten antibody and delayed hyper sensitivity responses. Immunology 28(5): 909-924, 1975

Cellular and humoral immune responses in mice part 3 acceleration of delayed hyper sensitivity response by pre sensitization with suboptimal dose of antigen. Immunology 30(5): 705-713, 1976

Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivity and antibody response. Immunology 32(3): 227-235, 1977

Cell mediated immunity delayed type hyper sensitivity and cyto toxic responses are mediated by different thymus derived cell subclasses. Journal of Experimental Medicine 143(6): 1534-1539, 1976

Regulation of the immune response part 1 suppression of delayed type hyper sensitivity by thymus derived cells from mice expressing humoral immunity. European Journal of Immunology 6(10): 674-679, 1976

Thymus derived cell sub populations suppressing humoral and delayed type hyper sensitivity responses. Journal of Supramolecular Structure SUPPL: 1, 1977