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Cells involved in the immune response xxxvi. the thymic antigen specific suppressor cell in the immunized rabbit is a t cell with receptors for fcg and the antigen and it acts via a secreted suppressor factor directly on the immune splenic afc b cell to inhibit antibody secretion



Cells involved in the immune response xxxvi. the thymic antigen specific suppressor cell in the immunized rabbit is a t cell with receptors for fcg and the antigen and it acts via a secreted suppressor factor directly on the immune splenic afc b cell to inhibit antibody secretion



Immunology 64(2): 253-260



Following i.v. immunization of the normal outbred rabbit with sheep (SRBC) or horse (HRBC) erythrocytes, antigen-specific suppressor cells are generated in the thymus capable of inhibiting the generation of haemolytic plaques by the autologous or allogeneic splenic antibody-forming cells (AFC) in the plaque-forming cell (PFC) assay. These suppressor cells secrete an antigen-specific suppressor factor in short-term (4-24 hr) culture in vitro. The suppressor cells are not detected in the thymus prior to Day 4, exhibit peak activity between Days 5 and 11 post-immunization, and decline slowly thereafter. Suppressor cells can no longer be detected in the thymus by Day 60 post-immunization. Suppressor cells are not detected in any of the other lymphoid organs of the immunized rabbit nor in any lymphoid organ in the unimmunized rabbit. The thymic suppressor cell is a T cell with surface receptors for the antigen (SRBC or HRBC) and for FcG. On the other hand, the AFCB cells generated in the spleen for the immunized rabbit possess cell-surface receptors for only the antigen and not for FcG. Both the suppressor cells and the secreted suppressor factor act directly on the AFC B lymphocytes to inhibit the generation of antigen-specific haemolytic plaques in the PFC assay.

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Accession: 004895003

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PMID: 2455684


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