Cerebral amyloidosis in scrapie in the mouse effect of agent strain and mouse genotype
Bruce, M.E.; Dickinson, A.G.; Fraser, H.
Neuropathology and Applied Neurobiology 2(6): 471-478
ISSN/ISBN: 0305-1846 DOI: 10.1111/j.1365-2990.1976.tb00521.x
Cerebral amyloid deposits, predominantly in the form of discrete plaques are common in mice infected with certain scrapie isolates. In this paper the incidences of cerebral amyloidosis occurring with different combinations of agent strain and mouse genotype are investigated. Seven different agents from 4 primary sources were studied in 3 mouse genotypes (C57BL, VM and their F1 cross). The degree of amyloidosis is apparently a passageable characteristic of the agent depending also on host genotype. However, the amyloid incidence is not influenced by the agent and mouse genotype independently but depends on a specific interaction between the 2. For 2 scrapie agents, 22A and ME7 there is a correlation between incubation period and the incidence of cerebral amyloid in the 3 mouse genotypes. The degree of cerebral amyloid for ME7 remains unaffected by passage through the 2 genotypes of mouse, C57BL and VM, and through another species, a Cheviot sheep.