Change of alpha 1 anti trypsin with trypsin a patient serum in auto immune disease

Matsuo, T.; Motomiya, Y.; Okajima, E.; Tatsumi, S.; Matsuoka, Y.; Umegaki, K.

Japanese Journal of Electrophoresis 24(4): 309-312

1981


Accession: 004904829

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Abstract
Serum level and profile of .alpha.1-antitrypsin (.alpha.1-AT) were studied in various autoimmune diseases such as SLE and hypergammaglobulinemia purpura. Serum level of .alpha.1-AT (in mg/dl) was 305 .+-. 95 in normal subjects, 428 .+-. 84 in SLE, 774 .+-. 204 in NP, 416 .+-. 104 in NS, 347 .+-. 33 in AGN, 421 .+-. 114 in CGN, 380 .+-. 46 in IgA N, 414 .+-. 52 in UC, 474 .+-. 53 in RA and 558 .+-. 167 in AIHA. The serum profile of .alpha.1-AT was analyzed by 2-dimensional immunoelectrophoresis after treatment with trypsin and was composed of 2 distinct forms, an active form and an inactive form. The ratio of active/inactive form was increased in all patients with autoimmune disease compared to the average value of 0.434 .+-. 0.020 in normal subjects. Serum .alpha.1-AT might be intimately anticipated with the inflammatory process in the autoimmune disease.