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Changes in guinea pig plasma cyclic nucleotide levels during the development of a transplantable leukemia



Changes in guinea pig plasma cyclic nucleotide levels during the development of a transplantable leukemia



Cancer 53(1): 79-82



Plasma levels of cAMP and cGMP were determined in 35 guinea pigs for up to 9 days following s.c. passage of L2C leukemia cells. Twenty guinea pigs into which normal syngeneic guinea pig thymocytes were passaged served as controls. Cyclic AMP levels in plasma showed little change and were only elevated significantly in test animals on day 9 after passage. In contrast cGMP levels reached a maximum on day 5 after passage of leukemia cells with 2- to 3-fold rises over day 1 levels. Increases in leukocyte counts were not observed until day 7 in test animals. Of the other tumor growth indices which were examined, the axillary (draining) node index gave the earliest indication of cell proliferation, with significant elevations on day 3 after passage. Plasma cGMP increases apparently precede increases in white cell counts by at least 2 days, and may reflect an early increase in axillary node growth.

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Accession: 004908258

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PMID: 6317160

DOI: 10.1002/1097-0142(19840101)53:1<79::aid-cncr2820530114>3.0.co;2-c


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