Changes in hypothalamic noradrenaline and 5 hydroxy tryptamine levels during the development of warm adaptation and cold adaptation in the rat

Hahn, Z.; Szelenyi, Z.

Acta Physiologica Academiae Scientiarum Hungaricae 54(3): 245-250

1979


ISSN/ISBN: 0001-6756
Accession: 004908583

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Abstract
Hypothalamic 5-hydroxytryptamine (5-HT; serotonin), hypothalamic noradrenaline (NA; norepinephrine) and plasma corticosterone levels were studied in male rats after 1, 2, 4 and 6 wk of exposure to 4-7 or 30-31.degree. C. An increase of the NA concentration and a decrease of the 5-HT level was observed after the 1st wk in both cold and warm environment together with an increase of plasma corticosterone levels in both groups. NA, 5-HT and plasma corticosterone levels returned to normal in cold-exposed animals by the 6th wk whereas in warm-acclimated rats NA and corticosterone levels regained their initial values and 5-HT concentrations remained low. Changes by the end of the 1st wk of exposure may result from the thermal stress. The low 5-HT levels of warm adapted animals at the end of the 6th wk were probably secondary to the process of adaptation.