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Changes in tissue and intestinal serotonin levels in the laboratory rat following feeding and the effect of serotonin inhibitors on the migratory response of hymenolepis diminuta cestoda



Changes in tissue and intestinal serotonin levels in the laboratory rat following feeding and the effect of serotonin inhibitors on the migratory response of hymenolepis diminuta cestoda



Canadian Journal of Zoology 60(5): 790-797



Following withdrawal of food for 24 h, rats infected with ten 11-day-old H. diminuta were given, via stomach tube, either 2 ml water, 1.2 mmol MgSO4 in 2 ml water, 1.2 .times. 10-3 mmol methysergide hydrogenmaleinate in 2 ml water, or 1.2 .times. 10-2 mmol methysergide in 2 ml water. After 30 min rats were again given access to food. In untreated control animals and in 2 further experimental groups which received either 2 ml water or 1.2 .times. 10-2 mmol methysergide in 2 ml water, food continued to be withheld after treatment. The amount of food ingested was determined, as well as changes in mucosal, luminal and worm serotonin (5-HT) levels. Changes in worm biomass distribution were also monitored. The addition of the specific 5-HT antagonist methysergide resulted in over a 90% inhibition in worm migratory response; MgSO4 resulted in 67% inhibition indicating a direct relationship between intestinal 5-HT levels and the distribution and the migratory behavior of H. diminuta within the intestinal lumen.

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Accession: 004916323

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Related references

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