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Changes of antibody dependent cell mediated cyto toxicity activity t cells bearing fc receptor for immuno globulin g and t lymphocyte and b lymphocyte sub populations in pregnant human peripheral blood



Changes of antibody dependent cell mediated cyto toxicity activity t cells bearing fc receptor for immuno globulin g and t lymphocyte and b lymphocyte sub populations in pregnant human peripheral blood



Acta Obstetrica et Gynaecologica Japonica (Japanese Edition) 34(10): 1699-1706



In peripheral blood of pregnant humans at various gestational weeks, antibody-dependent cell-mediated cytotoxicity (ADCC) activity was measured by microtest plate assays with sheep erythrocytes as target cells and T-cell populations bearing Fc receptors for IgG (T.gamma.-cells), and T and B lymphocyte and monocyte subpopulations by double rosette test. The materials were divided into 4 groups by each 10 wk period of gestation. ADCC activity, populations of T.gamma.-cells and T cell subpopulations were significantly depressed compared to the controls (P < 0.001) in every period of pregnancy, while the relative number of B cells was increased gradually from the 2nd period to term. The percent population of monocytes and double marker cells increased significantly only in the 1st period of pregnancy (P < 0.001). Percent population of null cells was depressed significantly except during the 3rd period (P < 0.01).

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Accession: 004916938

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