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Chemical properties of human hemoglobin modified by pyridoxal 5 phosphate and glutaraldehyde and model experiments on exchange transfusion in rats

Chemical properties of human hemoglobin modified by pyridoxal 5 phosphate and glutaraldehyde and model experiments on exchange transfusion in rats

Biologia (Bratislava) 42(7): 669-676

ISSN/ISBN: 0006-3088

A variant of oxygen-transporting haemoglobin solution was prepared by glutaraldehyde modification in the presence of pyridoxal-5-phosphate. This variant designated PHIR PG, like the previous one with serum albumin (PHIR P-G-A), represented as concerns electrophoretic mobility and molecular masses a polydisperse mixture in which modified haemoglobins with three maxima (240 000, 120 000 and 43 000) prevailed. The PHIR PG variant showed an ability to oxygen transfer by about one third lower than the PHIR P-G-A variant. After exchange transfusion in rats, the intravascular half-life was prolonged to 18 .+-. 2 h. The animals survived exchange transfusion of up to 94% of their blood without complications.

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Accession: 004938996

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