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Chemo therapeutic studies on n nitrosoacetoxymethyl methylamine induced and 1 2 di methyl hydrazine induced colonic tumors in rats mono therapy with 5 fluoro uracil ftorafur cgp 6809 and cgp 15720a



Chemo therapeutic studies on n nitrosoacetoxymethyl methylamine induced and 1 2 di methyl hydrazine induced colonic tumors in rats mono therapy with 5 fluoro uracil ftorafur cgp 6809 and cgp 15720a



Journal of Cancer Research & Clinical Oncology 104(1-2): 115-132



Colonic tumors were induced in male Sprague-Dawley rats by 10 applications of 2 mg/kg per wk N-nitrosoacetoxymethyl-methylamine (AMMN) or by 3 applications of 100 mg/kg per mo. 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29-42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809 and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.

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Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. Journal of Cancer Research and Clinical Oncology 104(1-2): 115-131, 1982

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