Chemo therapy of testicular tumor cis di ammine di chloro platinum single and cis di ammine di chloro platinum vinblastine and bleomycin combination

Obata, K.; Natsume, H.; Murase, T.; Honda, N.; Ando, M.; Sakata, T.; Ito, H.; Kobayashi, H.

Acta Urologica Japonica 28(Suppl 1): 59-65


Accession: 004941473

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Nine patients with testicular tumors were treated with CDDP [cis-diamminedichloroplatinum] and the combination of CDDP, vinblastine and bleomycin to treat metastasis. All 4 patients receiving a single administration of CDDP could not achieve a sufficient response. Four of 6 patients treated with CDDP, vinblastine and bleomycin had measurable lung tumors; 3 of them achieved objective response; 1 complete (25%) and 2 partial (50%). Nausea and vomiting were observed in almost all patients, especially in the 3 drug combination therapy. Renal toxicity of CDDP was reduced under sufficient hydration. Leukopenia and thrombocytopenia were seen only in the patients who received combination chemotherapy.